diff --git a/be/CMakeLists.txt b/be/CMakeLists.txt
index 74c0e998226491..cfa5a0552a3edc 100644
--- a/be/CMakeLists.txt
+++ b/be/CMakeLists.txt
@@ -470,7 +470,10 @@ set(CXX_FLAGS_ASAN_UT "-O0 -fsanitize=address -DADDRESS_SANITIZER")
 
 # Set the flags to the undefined behavior sanitizer, also known as "ubsan"
 # Turn on sanitizer and debug symbols to get stack traces:
-set(CXX_FLAGS_UBSAN "-O0 -fno-wrapv -mcmodel=medium -fsanitize=undefined -DUNDEFINED_BEHAVIOR_SANITIZER")
+set(CXX_FLAGS_UBSAN "-O0 -fno-wrapv -fsanitize=undefined -DUNDEFINED_BEHAVIOR_SANITIZER")
+if (ARCH_AMD64)
+    set(CXX_FLAGS_UBSAN "${CXX_FLAGS_UBSAN} -mcmodel=medium")
+endif()
 
 # Set the flags to the thread sanitizer, also known as "tsan"
 # Turn on sanitizer and debug symbols to get stack traces:
diff --git a/be/src/common/phdr_cache.cpp b/be/src/common/phdr_cache.cpp
index e0f5ff43fed6a5..deb543bc3716a6 100644
--- a/be/src/common/phdr_cache.cpp
+++ b/be/src/common/phdr_cache.cpp
@@ -107,7 +107,7 @@ extern "C"
 */
 
 extern "C" {
-#ifdef ADDRESS_SANITIZER
+#if defined(ADDRESS_SANITIZER) || defined(LEAK_SANITIZER)
 void __lsan_ignore_object(const void*);
 #else
 void __lsan_ignore_object(const void*) {} // NOLINT
diff --git a/be/src/storage/index/ann/cmake-protect/CMakeLists.txt b/be/src/storage/index/ann/cmake-protect/CMakeLists.txt
index 0c65e4ae170f7e..c5c35c1c32a077 100644
--- a/be/src/storage/index/ann/cmake-protect/CMakeLists.txt
+++ b/be/src/storage/index/ann/cmake-protect/CMakeLists.txt
@@ -16,6 +16,19 @@
 # under the License.
 
 # Make sure compile check in doris will not break compilation of faiss and openblas
+# Strip sanitizer flags to prevent build-time tools (e.g., openblas getarch) from
+# triggering LeakSanitizer/AddressSanitizer errors during CMake configure phase
+string(REGEX REPLACE "-fsanitize=[a-z,=_./-]+" "" CMAKE_C_FLAGS "${CMAKE_C_FLAGS}")
+string(REGEX REPLACE "-fsanitize=[a-z,=_./-]+" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
+string(REGEX REPLACE "-fno-sanitize=[a-z,=_./-]+" "" CMAKE_C_FLAGS "${CMAKE_C_FLAGS}")
+string(REGEX REPLACE "-fno-sanitize=[a-z,=_./-]+" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
+string(REGEX REPLACE "-fsanitize-ignorelist=[a-z,=_./-]+" "" CMAKE_C_FLAGS "${CMAKE_C_FLAGS}")
+string(REGEX REPLACE "-fsanitize-ignorelist=[a-z,=_./-]+" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
+string(REGEX REPLACE "-D[A-Z_]+SANITIZER" "" CMAKE_C_FLAGS "${CMAKE_C_FLAGS}")
+string(REGEX REPLACE "-D[A-Z_]+SANITIZER" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
+# Strip -mcmodel= which is x86_64-specific and unsupported on aarch64
+string(REGEX REPLACE "-mcmodel=[a-z]+" "" CMAKE_C_FLAGS "${CMAKE_C_FLAGS}")
+string(REGEX REPLACE "-mcmodel=[a-z]+" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
 set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -w")
 set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -w")