diff --git a/packages/main/cypress/specs/List.cy.tsx b/packages/main/cypress/specs/List.cy.tsx
index 0e3acd85315d..4a3df3d1ed45 100644
--- a/packages/main/cypress/specs/List.cy.tsx
+++ b/packages/main/cypress/specs/List.cy.tsx
@@ -378,7 +378,7 @@ describe("List - Accessibility", () => {
 
 	it("has default aria-description for accessibleRole List when no accessibleDescription is set", () => {
 		cy.mount(
-			<List>
+			<List selectionMode="Delete">
 				<ListItemStandard>Item 1</ListItemStandard>
 				<ListItemStandard>Item 2</ListItemStandard>
 			</List>
@@ -413,7 +413,7 @@ describe("List - Accessibility", () => {
 		const customDescription = "Custom list description";
 
 		cy.mount(
-			<List accessibleDescription={customDescription}>
+			<List selectionMode="Delete" accessibleDescription={customDescription}>
 				<ListItemStandard>Item 1</ListItemStandard>
 				<ListItemStandard>Item 2</ListItemStandard>
 			</List>
@@ -457,6 +457,91 @@ describe("List - Accessibility", () => {
 					});
 			});
 	});
+
+	it("does not announce F2 instruction for selectionMode None with standard items", () => {
+		cy.mount(
+			<List selectionMode="None">
+				<ListItemStandard>Item 1</ListItemStandard>
+				<ListItemStandard>Item 2</ListItemStandard>
+			</List>
+		);
+
+		cy.get("[ui5-list]")
+			.shadow()
+			.find(".ui5-list-ul")
+			.invoke("attr", "aria-description")
+			.then((ariaDesc) => {
+				cy.get("[ui5-list]")
+					.should(($list) => {
+						const defaultText = $list.prop("defaultAriaDescriptionText") as string;
+						expect(ariaDesc ?? "").to.not.include(defaultText);
+					});
+			});
+	});
+
+	it("announces F2 instruction for selectionMode Delete", () => {
+		cy.mount(
+			<List selectionMode="Delete">
+				<ListItemStandard>Item 1</ListItemStandard>
+				<ListItemStandard>Item 2</ListItemStandard>
+			</List>
+		);
+
+		cy.get("[ui5-list]")
+			.shadow()
+			.find(".ui5-list-ul")
+			.invoke("attr", "aria-description")
+			.then((ariaDesc) => {
+				cy.get("[ui5-list]")
+					.should(($list) => {
+						const defaultText = $list.prop("defaultAriaDescriptionText") as string;
+						expect(ariaDesc).to.include(defaultText);
+					});
+			});
+	});
+
+	it("announces F2 instruction for selectionMode None with type Detail items", () => {
+		cy.mount(
+			<List selectionMode="None">
+				<ListItemStandard type="Detail">Item 1</ListItemStandard>
+				<ListItemStandard type="Detail">Item 2</ListItemStandard>
+			</List>
+		);
+
+		cy.get("[ui5-list]")
+			.shadow()
+			.find(".ui5-list-ul")
+			.invoke("attr", "aria-description")
+			.then((ariaDesc) => {
+				cy.get("[ui5-list]")
+					.should(($list) => {
+						const defaultText = $list.prop("defaultAriaDescriptionText") as string;
+						expect(ariaDesc).to.include(defaultText);
+					});
+			});
+	});
+
+	it("announces F2 instruction for selectionMode None with custom list items", () => {
+		cy.mount(
+			<List selectionMode="None">
+				<ListItemCustom>
+					<Button>Action</Button>
+				</ListItemCustom>
+			</List>
+		);
+
+		cy.get("[ui5-list]")
+			.shadow()
+			.find(".ui5-list-ul")
+			.invoke("attr", "aria-description")
+			.then((ariaDesc) => {
+				cy.get("[ui5-list]")
+					.should(($list) => {
+						const defaultText = $list.prop("defaultAriaDescriptionText") as string;
+						expect(ariaDesc).to.include(defaultText);
+					});
+			});
+	});
 });
 
 describe("List - Wrapping Behavior", () => {
diff --git a/packages/main/src/List.ts b/packages/main/src/List.ts
index 4ce0a29f3332..9216409e8a4e 100644
--- a/packages/main/src/List.ts
+++ b/packages/main/src/List.ts
@@ -742,7 +742,7 @@ class List extends UI5Element {
 	get ariaDescriptionText() {
 		const parts = [];
 
-		if (this.accessibleRole === ListAccessibleRole.List) {
+		if (this.accessibleRole === ListAccessibleRole.List && this._hasInteractiveItems) {
 			parts.push(this.defaultAriaDescriptionText);
 		}
 		const externalDescription = this._associatedDescriptionRefTexts || getEffectiveAriaDescriptionText(this);
@@ -763,6 +763,16 @@ class List extends UI5Element {
 		return List.i18nBundle.getText(LIST_ROLE_DESCRIPTION);
 	}
 
+	get _hasInteractiveItems() {
+		if (this.selectionMode === ListSelectionMode.Delete) {
+			return true;
+		}
+
+		return this.getItems().some(item => {
+			return item.getAttribute("type") === "Detail" || item.hasAttribute("ui5-li-custom");
+		});
+	}
+
 	get growingButtonAriaLabel() {
 		return this.accessibilityAttributes.growingButton?.name;
 	}